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Respiratory disease in calves is an interaction between the environment, the immunity of the calf and the various infectious agents involved. The most important agents are Infectious Bovine Rhinotracheitis (IBR), Bovine Respiratory Syncytial Virus (RSV), Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Parainfluenza-3 Virus (PI3).